INHIBITORY EFFECT OF (+)THREO-3,4-DIHYDROXY-PHENYLSERINE (DOPS) ON DECARBOXYLATION OF (−)THREO-DOPS

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Inhibitory effect of (+)threo-3,4-dihydroxy-phenylserine (DOPS) on decarboxylation of (-)threo-dops.

The decarboxylation of racemic threo and erythro-3,4-dihydroxyphenylserine (DOPS), norepinephrine (NE) precursors, has been reported in mammalian peripheral and central nervous system tissues in vivo (1-5). It has also been demonstrated both in vitro and in vivo that the rate of racemic erythro-DOPS decarboxylation is more rapid than that of racemic threo-DOPS (6). A recent report on the action...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1976

ISSN: 0021-5198

DOI: 10.1254/jjp.26.380